盐酸二甲双胍是 95药典新增降糖药物 ,有关其测定方法国内外报道较少[1,2 ] ,我国药典规定为非水滴定法和吸光光度法[3 ] 。这些方法均需较复杂的样品处理 ,分析过程冗长 ,影响分析速度。本文提出的两点电位滴定法只需记录滴定终点前附近的两组滴定数据 ,由相应公式计算滴定终 Metformin Hydrochloride is a new Pharmacopoeia of Pharmacopoeia 95 hypoglycemic drugs, the determination of its less reported at home and abroad [1,2], China’s pharmacopoeia for non-aqueous titration and spectrophotometry [3]. These methods require more complex sample processing, the analysis process is lengthy, affecting the analysis speed. The two-point potentiometric titration proposed in this paper only needs to record two sets of titration data in the vicinity of the titration endpoint, and the titration is calculated by the corresponding formula