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本文研究了含丰富HDL的雄性北京鸭,对胆固醇(Ch)的代谢特点及其与抗动脉粥样硬化(AT)的关系。在18周饲养高Ch和高脂肪饲料期间,实验组(16只)血清Ch和HDL-Ch与对照组(14只)比在8周后均有明显增加,分别平均从132±20mg/dl最高增加到158±28mg/dl,从81±15mg/dl最高增加到115±9mg/dl,血请βLP仅在8周时略有增加,α和βLP％量则基本不变,甘油三脂和LCAT酶活性二组间无显著差异,PAG电泳显示蛋白染色二组无明显差异,脂质染色HDL带变宽,说明北京鸭主要由血清HDL运转外源性Ch,此外,二组主动咏均无粥样硬化斑块形成,仅有脂肪条纹。本实验为以HDL作为运转Ch者的动物有抗AT作用提供了有力的实验依据。
In this paper, we studied the metabolic characteristics of Cholesterol (Ch) and its relationship with anti-atherosclerosis (AT) in male Beijing duck with rich HDL. During 18 weeks of feeding high-Ch and high-fat diets, serum Ch and HDL-Ch in the experimental group (16) increased significantly compared with the control group (14) after 8 weeks, with an average increase from 132 ± 20 mg / dl 158 ± 28 mg / dl, increasing from 81 ± 15 mg / dl up to 115 ± 9 mg / dl. Blood application of βLP increased slightly only at 8 weeks, and the amounts of α and βLP% remained unchanged. Triglyceride and LCAT enzyme activity No significant difference between the two groups, PAG electrophoresis showed no significant difference in the two groups of protein staining, lipid-dyed HDL band broadened, indicating that Beijing duck mainly by the operation of serum HDL exogenous Ch, in addition, the two groups were active atherogenic no atherosclerosis Plaque formation, only fatty streaks. This experiment provides a powerful experimental basis for the use of HDL as an anti-AT in animals operating Ch.