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目的探讨基质金属蛋白酶(MMP-2、MMP-9)及其抑制剂(TIMP-1、TIMP-2)和细胞粘附分子CD15在肺癌浸润和转移中的作用,是否能为临床肺癌的诊断和治疗提供一种新的、有效的手段。方法通过免疫组化方法检测47例肺癌标本中MMP-2、MMP-9、TIMP-1、TIMP-2和CD15的表达情况。结果腺癌中MMP-2、TIMP-1阳性表达率明显高于鳞癌(P<0.01),鳞癌中MMP-9的阳性表达率高于腺癌(P<0.01);低分化者MMP-9的阳性表达率高于高、中分化者(P<0.05);有淋巴结转移者MMP-2、MMP-9和CD15的阳性表达率高于无淋巴结转移者(P<0.01);无淋巴结转移者中TIMP-1的阳性表达率高于有淋巴结转移者。结论肺癌组织中MMP-2、MMP-9、TIMP-1和CD15的阳性表达可能是肺癌恶性程度和预后判断的指标。
Objective To investigate the role of matrix metalloproteinase (MMP-2, MMP-9) and its inhibitor (TIMP-1, TIMP-2) and cell adhesion molecule CD15 in lung cancer invasion and metastasis, Treatment provides a new and effective means. Methods Immunohistochemistry was used to detect the expression of MMP-2, MMP-9, TIMP-1, TIMP-2 and CD15 in 47 cases of lung cancer. Results The positive rates of MMP-2 and TIMP-1 in adenocarcinoma were significantly higher than those in squamous cell carcinoma (P <0.01), while the positive rates of MMP-9 in squamous cell carcinoma were higher than those in adenocarcinoma (P <0.01) 9 was higher than that in the patients with high or moderate differentiation (P <0.05). The positive rates of MMP-2, MMP-9 and CD15 in patients with lymph node metastasis were higher than those without lymph node metastasis (P <0.01) The positive expression rate of TIMP-1 was higher than those with lymph node metastasis. Conclusion The positive expression of MMP-2, MMP-9, TIMP-1 and CD15 in lung cancer may be an indicator of malignancy and prognosis of lung cancer.