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目的:了解2006～2008年我院药品不良反应(ADR)发生情况,探讨引发因素,为临床合理用药提供参考。方法:对2006～2008年医院上报的476例ADR报告进行回顾分析。结果:ADR发生于各个年龄组,<10岁年龄组中ADR病例占25.21%(120例);ADR病例男女比例为1:1.13;住院与留院观察病例占79.41%(398例);临床科室上报占86.76%(413例);一般或常见的ADR占91.60%(436例);以静脉给药的方式引发的ADR为主,占86.55%(412例);抗感染药物引起ADR为最多,占总数的69.96%(333例),中药引起的ADR占总数的5.67%(27例);临床表现以皮肤及附属器官损伤最常见,占69.54%(331例)。结论:加强ADR监测工作,可促进合理用药,保障用药安全。
Objective: To understand the incidence of adverse drug reaction (ADR) in our hospital from 2006 to 2008, explore the triggering factors and provide a reference for clinical rational drug use. Methods: A retrospective analysis of 476 ADR reports reported by hospitals from 2006 to 2008 was conducted. Results: ADR occurred in all age groups, ADR cases in 10-year-old age group accounted for 25.21% (120 cases); ADR cases male to female ratio was 1: 1.13; Hospitalization and hospital stay cases accounted for 79.41% (398 cases) Reported 86.76% (413 cases); common or common ADR accounted for 91.60% (436 cases); intravenous administration induced ADR, accounting for 86.55% (412 cases); anti-infectives caused the most ADR, Accounting for 69.96% (333 cases) of the total, and 5.67% (27 cases) of ADR caused by traditional Chinese medicine. The most common manifestations were skin and accessory organs, accounting for 69.54% (331 cases). Conclusion: To strengthen the monitoring of ADR can promote rational drug use and ensure drug safety.