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作为抗心律不齐、表麻与局麻的药剂盐酸利多卡因应用广泛。本文报告一例二岁半女婴,因患口腔念珠菌病在当地医院诊治,医生除给予口服制霉菌素溶液外,又嘱患儿母亲,每次喂食时滴2、3滴利多卡因在患儿舌上,以缓解疼痛。住院当天,用药后立即出现青紫及呼吸困难,继之全身持续抽搐数分钟,经复苏及安装辅助呼吸器后转至作者医院。住院体检,患儿全无反应,无自主呼吸,瞳孔缩小至针尖大,对光反应极度迟钝,眼底静脉搏动减弱,深反射消失。血清利多卡因含量3.2mg/L。患儿于入院10天后死亡。尸检发现有脑水肿,小脑脑疝形成,脑组织严重缺氧,病变累及大脑、基底部和脑干核。在讨论中,作者提出,患儿的利多卡因摄入量已超过医生处方,每天治疗量约达每公斤体重30mg,其血清利多卡因浓度虽在中毒量5mg/L以下,但这是
As anti-arrhythmic, ephedrine and local anesthetic lidocaine hydrochloride is widely used. This article reports a two-and-a-half-year-old baby girl, suffering from oral candidiasis at a local hospital for diagnosis and treatment. In addition to oral administration of nystatin solution, the doctor gave mothers and mothers a dose of 2, 3 drops of lidocaine at each feeding Pediatric tongue to relieve pain. On the day of hospitalization, bruising and dyspnea appeared immediately after treatment, followed by continuous convulsions throughout the body for several minutes. After resuscitation and installation of a ventilator, they were transferred to the author’s hospital. Hospitalization, no reaction in children, no spontaneous breathing, pupil narrowing to the needle tip, extremely slow response to light, reduced fundic venous pulsation, deep reflex disappeared. Serum lidocaine content 3.2mg / L. Children died 10 days after admission. Autopsy found brain edema, cerebellar hernia formation, severe hypoxic brain tissue, lesions involving the brain, basal ganglia and brain stem. In the discussion, the authors suggest that the lidocaine intake in children has exceeded the doctor’s prescription, the daily dose of about 30mg per kilogram of body weight, although the concentration of serum lidocaine poisoning in the amount of 5mg / L or less, but this is