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回顾性总结了１２例急进性肾炎（ＲＰＧＮ）患者的临床表现、实验室及病理资料及对不同治疗方法的反应，结果显示：原发性ＲＰＧＮ９例、免疫球蛋白Ａ肾病、系统性红斑狼疮、Ｇｏｏｄ－Ｐａｓｔｕｒｅ综合征各１例。１２例患者均表现不同程度的蛋白尿、血尿，其中４例表现为肾病综合征（ＮＳ），４例呈发作性肉眼血尿，７例血压增高；３例经糖皮质激素、环磷酰胺冲击或血浆置换治疗后肾功能基本恢复，其余７例依赖长期透析存活，２例死亡。早期诊断、早期治疗是减少病死率的关键。
The clinical manifestations, laboratory and pathological data of 12 patients with radical nephritis (RPGN) were retrospectively reviewed. The results showed that there were 9 cases of primary RPGN, immunoglobulin A nephropathy, systemic lupus erythematosus, Good-Pasture syndrome in 1 case. All 12 patients showed different degrees of proteinuria and hematuria. Among them, 4 cases showed nephrotic syndrome (NS), 4 cases had gross hematuria and 7 cases had high blood pressure. Three cases were treated with glucocorticoid, cyclophosphamide or Renal function basically recovered after plasma exchange treatment, and the remaining 7 patients were dependent on long-term dialysis survival and 2 died. Early diagnosis, early treatment is the key to reducing mortality.