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作者报告1例罕见的下颌骨前部的变异型颗粒细胞造釉细胞瘤,呈无痛性慢性生长,病史15年。X 片示(?)牙槽骨皂泡样透光区。活检报告为“上皮性大嗜粒酸细胞瘤”,切除后光镜见二型瘤细胞巢。大巢由含少量嗜酸性颗粒的胞浆和深染的小泡性核的颗粒细胞组成。颗粒呈PAS 阳性,巢周围细胞大而呈柱状,核位于细胞近心部,丝状核分裂少见,瘤巢间有纤细的实质。其余部位见滤泡型造釉细胞瘤。超微结构见一组瘤细胞呈现假颗粒结构,高柱状,胞浆中有丰富的溶酶体颗粒,呈“指印样”结构,细胞近心部散布少量线粒体,染色质呈小泡状分布的核位于细胞近心部。本例组织学上与通常型颗粒细胞造釉细胞瘤的区别为:(1)瘤巢的全部细胞都仅由颗粒细胞组成;
The authors reported a rare case of an ameloblastoma of the granulosa cell anterior to the mandible that showed painless chronic growth for 15 years. X-rays show (?) alveolar bone soap bubble-like light transmission area. The biopsy report was “epithelial macrogranuloma.” After resection, light microscopy showed a nest of bioma cells. The large nest consists of cytoplasm containing a small amount of eosinophilic particles and granulosa cells of a deeply stained vesicular nucleus. The particles were PAS-positive, the cells around the nest were large and columnar, the nucleus was located in the proximal part of the cell, and the filiform nucleus was rarely divided, and there was a slender nature between the tumor nests. Follicular ameloblastomas are found elsewhere. The ultrastructure of a group of tumor cells showed a pseudo-granular structure, high columnar, abundant lysosomal granules in the cytoplasm, a “fingerprint-like” structure, a small amount of mitochondria scattered in the proximal part of the cell, and the chromatin was distributed in a small bubble. The nucleus is located in the proximal part of the cell. In this case, the difference between histologically and normal granulosa cell ameloblastoma was: (1) All cells in the tumor nest consisted only of granulosa cells;