本文报道以二甲肼诱发的大肠癌小鼠为动物模型,于肿瘤生长的不同阶段,分别测定其脾细胞产生IL-2能力,对ConA的增殖反应及NK细胞活性。结果表明,荷瘤鼠脾细胞产生IL-2能力和对ConA的增殖反应均明显受到抑制,且随荷瘤期的延长其受抑制程度加剧,但荷瘤鼠的NK细胞活性变化与对照鼠无显著差异。 In this paper, we report that mice with colorectal cancer induced by dimethyl hydrazine were used as animal models. At different stages of tumor growth, the ability of spleen cells to produce IL-2, the proliferation response to ConA, and the activity of NK cells were measured. The results showed that IL-2 production ability and ConA proliferative response in tumor-bearing mice spleen cells were significantly inhibited, and with the prolongation of the tumor-bearing period, the inhibition was intensified, but the activity of NK cells in the tumor-bearing mice and the control mice were absent. Significant differences.