论文部分内容阅读
以高效液相色谱法测定人血清中阿莫西林，以进口阿莫西林片为参比制剂，研究了国产阿莫西林片的相对生物利用度。结果表明，国产和进口片的药－时曲线均符合一级吸收的二房室模型，两药的药代动力学参数间均无显著性差异，国产片的相对生物利用度为９９．１％。
The determination of amoxicillin in human serum by HPLC and the comparison of the relative bioavailability of amoxicillin tablets in China with imported amoxicillin tablets as reference preparation. The results showed that the drug-time curves of domestic and imported tablets were in accordance with the two-compartment model of primary absorption. There was no significant difference in the pharmacokinetic parameters between the two drugs. The relative bioavailability of domestic tablets was 99.1%.