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本文综述了乳腺癌易感基因BRCA1生物学特性研究进展。在阐明BRCA1基因结构特点的基础上,着重介绍了它作为一种新的肿瘤抑制基因在细胞生长发育、核转录调控及DNA损伤修复中的作用。
This review summarizes the research progress on the biological characteristics of breast cancer susceptibility gene BRCA1. On the basis of elucidating the structural features of BRCA1 gene, the role of BRCA1 as a novel tumor suppressor gene in cell growth and development, nuclear transcription regulation and repair of DNA damage is emphatically introduced.