N-(3’,4’,5’-三甲氧基肉桂酰)邻氨基苯甲酸(TOA)(100 mg·km~(-1)ip)显著抑制同系大鼠被动皮肤过敏反应(PCA)。剂量为 50和100 mg·kg~(-1)·d~(-1),ip×4d时,明显抑制大鼠反相皮肤过敏反应(RCA)。致敏同时给药(50和100mg kg~(-1)·d~(-1),ip×6d)或攻击前给药(100mg·kg~(-1)·d~(-1),ip×2d),TOA对SRBC诱导的小鼠迟发型过敏反应(DTH)均有明显抑制作用。剂量为 50和100 mg·kg~(-1)ip时,TOA对大鼠皮内注时组胺及5-羟色胺(5-HT)引起的毛细血管通透性增加均有显著拮抗作用。 TOA (100 mg · km ~ (-1) ip) significantly inhibited passive cutaneous anaphylaxis (PCA) in sibling rats. At doses of 50 and 100 mg · kg -1 · d ~ (-1), the reverse phase skin anaphylaxis (RCA) in rats was significantly inhibited at ip x 4 d. At the same time, the sensitized rats were administered with either 50 and 100 mg kg -1 d -1 ip 6 days or 100 mg kg -1 d -1 ip × 2d), TOA inhibited SRBC-induced delayed-type hypersensitivity (DTH) in mice. At doses of 50 and 100 mg · kg -1 ip, TOA markedly antagonized the increase of capillary permeability induced by intradermal injection of histamine and 5-hydroxytryptamine (5-HT) in rats.