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在血吸虫、疟疾等寄生虫病的实验研究中曾证明循环免疫复合物(CIC)可引起免疫抑制。本实验检测了蒙古沙鼠在感染彭亨丝虫后11个月中的CIC水平,并探讨了CIC水平与丝虫生活史各发育阶段的关系。作者以彭亨丝虫人工感染16只2月龄的雄性沙鼠,每只腹腔接种75条感染期幼虫。感染前2周、感染后每隔1个月自眶窦各取血1次,分离血清,连续11个月,并以8只年龄、性别配对的沙鼠作为对照组。采用固相C_(10)结合试验检测CIC。检测前血清存放在-70℃。
In experimental studies on parasitic diseases such as schistosomiasis and malaria, it has been demonstrated that circulating immune complexes (CICs) can cause immunosuppression. The present study examined the Mongolian gerbils in the penicillium infection Penicillium 11 months after the CIC level and explore CIC levels and filarial life history of the various stages of development. The authors used penicillium filariasis artificial infection of 16 two-month-old male gerbils, each inoculated 75 infected larvae. Two weeks before infection, blood was taken from the orbital sinus once every 1 month after infection, and the serum was separated for 11 consecutive months. Eight gerbils matched with age and sex were used as the control group. CIC was detected by solid phase C_ (10) binding assay. Pre-test serum stored at -70 ℃.