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目的分析新登记肺结核患者的初始耐药情况,为进一步控制肺结核的发病和流行提供依据。方法对杭州市红十字会医院2012年新登记的活动性肺结核患者进行痰培养获得768株分枝杆菌菌株,对培养阳性菌株进行菌型鉴定并用比例法进行药物敏感性试验。结果 2012年非结核分枝杆菌(NTM)分离率为4.42%,结核分枝杆菌(MTB)初始耐药率13.35%,耐多药率4.50%,耐单药率从高到低为INH(8.31%)、RFP(7.22%)、SM(6.40%)和EMB(2.45%)。耐药率随年龄增长呈下降趋势,16岁~组人群初始耐药率明显高于61岁及以上年龄组。结论青壮年肺结核患者初始耐药率高,应加强对重点人群的管理及随访。
Objective To analyze the initial drug resistance of newly registered patients with pulmonary tuberculosis and provide basis for further controlling the incidence and prevalence of pulmonary tuberculosis. Methods A total of 768 mycobacteria strains were obtained from sputum culture of newly registered patients with active pulmonary tuberculosis in Hangzhou Red Cross Hospital in 2012. The positive strains were identified for their mycobacteria culture and drug sensitivity test was carried out by proportional method. Results The isolation rate of NTM in 2012 was 4.42%, the initial resistance rate of MTB was 13.35%, the multi-drug resistance rate was 4.50%, and the single drug resistance rate was INH (8.31 %), RFP (7.22%), SM (6.40%) and EMB (2.45%). The drug resistance rate showed a declining trend with age. The initial drug resistance rate of 16-year-old group was significantly higher than that of 61-year-old and above age group. Conclusion Young patients with high initial TB rate of tuberculosis should strengthen the management of key populations and follow-up.