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为了深入研究人肝癌,我室在大鼠肝癌模型研究的基础上,开展了裸鼠人体肝癌模型的研究。1982年建成我国第一株裸小鼠人肝癌移植模型。至今,5例人肝癌手术标本已成功移植于裸小鼠,并进行了肿瘤形态学、甲胎蛋白、铁蛋白、阳性扫描等多种研究。但裸小鼠人肝癌模型仍有一定的不足之处:1.所获瘤组织较少;2.所能提供的血量较少;3.裸小鼠难于施行某些外科小手术及肝内移植。为了弥补上述不足,我室于1983年引入
In order to study human liver cancer further, our laboratory developed a human hepatoma model of nude mice based on the study of rat liver cancer model. In 1982, China’s first nude mouse human liver cancer transplantation model was established. So far, 5 cases of human liver cancer surgical specimens have been successfully transplanted in nude mice, and carried out a variety of studies such as tumor morphology, alpha-fetoprotein, ferritin, and positive scans. However, the model of human hepatocellular carcinoma in nude mice still has certain deficiencies: 1. The tumor tissue obtained is less; 2. The amount of blood that can be provided is less; 3. nude mice are difficult to perform certain surgical minor operations and intrahepatic transplant. In order to make up for the above deficiencies, our room was introduced in 1983