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目的探讨HIF-1α在胃腺癌组织中的表达意义,及其与P-gp、MRP1之间的关系。方法应用免疫组织化学SP法检测45例胃腺癌组织的蜡块及10例胃镜下活检胃炎组织中HIF-1α、P-gp和MRP1的表达。结果HIF-1α在胃腺癌组织中阳性表达率为46.7%,在胃炎组织中不表达,两者相比差异有统计学意义(P<0.05);其中HIF-1α表达与淋巴结转移和肿瘤浸润深度有关(P<0.05);HIF-1α表达分别与P-gp、MRP1表达呈正相关(rs=0.504,P<0.01;rs=0.357,P<0.05)。结论HIF-1α是反应胃腺癌的浸润转移生物学行为的参考指标之一,并对胃腺癌细胞内P-gp、MRP1的表达有促进作用,在胃腺癌耐药产生中起一定的作用。
Objective To investigate the expression of HIF-1α in gastric adenocarcinoma and its relationship with P-gp and MRP1. Methods Immunohistochemical SP method was used to detect the expression of HIF-1α, P-gp and MRP1 in 45 cases of gastric adenocarcinoma and 10 cases of endoscopic gastritis under endoscopy. Results The positive rate of HIF-1alpha in gastric adenocarcinoma was 46.7%, but not in gastritis tissues (P <0.05). The expression of HIF-1alpha was correlated with lymph node metastasis and depth of tumor infiltration (P <0.05). The expression of HIF-1α was positively correlated with the expression of P-gp and MRP1 (rs = 0.504, P <0.01; rs = 0.357, P <0.05). Conclusions HIF-1α is one of the reference parameters that can reflect the biological behavior of gastric adenocarcinoma in invasion and metastasis, and promotes the expression of P-gp and MRP1 in gastric adenocarcinoma and plays a role in the drug resistance of gastric adenocarcinoma.