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目的:探讨术中加用温水浴疗的安全性和对肝癌(HCC)切除术疗效的影响。方法:回顾性分析3年间行术中温水浴疗治疗(肝切除术后余肝温水浸浴1 h)35例HCC患者(手术加浴疗组,浴疗组)临床资料,并选取同期同样例数的行单纯肝切除(手术组)和肝切除加介入(手术加介入组,介入组)的HCC患者资料进行比较。结果:温水浴疗组术后各免疫球蛋白及可溶性白细胞介素2受体(sIL-2R)水平较术前明显升高(均P<0.05),而其他两组无此改变;在复发率与生存率方面,浴疗组与介入组无统计学差异(均P>0.05),但均优于手术组(均P<0.05);在住院费用和患者痛苦方面,介入组较浴疗组与手术组增加;各组间术后并发症发生率无统计学差异(P>0.05)。结论:肝切除加术中温水浴疗是HCC安全、有效的治疗方法。它能提高患者术后免疫功能,降低术后复发率,延长患者的生存时间。
Objective: To investigate the safety of intraoperative warm water bath and the effect on the curative effect of hepatocellular carcinoma (HCC) resection. Methods: The clinical data of 35 HCC patients (operation plus bath therapy group and bath therapy group) undergoing warm water bath therapy after operation (1 h after liver resection after liver resection) were retrospectively analyzed. The same period The number of simple liver resection (surgery group) and liver resection plus intervention (surgery plus intervention group, intervention group) HCC patients were compared. Results: The levels of serum immunoglobulin and soluble interleukin 2 receptor (sIL-2R) in warm water bath group were significantly higher than those before operation (all P <0.05), while the other two groups had no change. The recurrence rate There was no significant difference between the treatment group and the intervention group (all P> 0.05), but both were better than the operation group (all P <0.05). In terms of hospitalization costs and patient’s pain, There was no significant difference in postoperative complication between the two groups (P> 0.05). Conclusions: Hepatectomy plus intraoperative warm bath therapy is a safe and effective treatment for HCC. It can improve postoperative immune function, reduce postoperative recurrence rate and prolong patient’s survival time.