论文部分内容阅读
目的分析C反应蛋白(CRP)和血清前白蛋白(PA)在高龄慢性阻塞性肺疾病急性加重期(AECOPD)治疗前后的变化规律,探讨其在高龄AECOPD病情监测和预后中的意义。方法选择老年AECOPD住院患者65例(年龄≥80岁),检测其治疗前后体温、血清白细胞计数(WBC)、中性粒细胞、CRP、PA和腺苷脱氨酶(ADA)水平动态变化情况。结果高龄AECOPD患者血清CRP水平显著升高,PA水平显著下降;治疗后CRP水平明显降低(P<0.01),PA水平明显升高(P<0.01)。治疗前后T、白细胞、中性粒细胞和ADA水平变化不明显,差异无统计学意义(P>0.05)。结论高龄AECOPD患者血清CRP、PA水平在有效抗感染治疗后发生明显变化,敏感性优于体温、白细胞、中性粒细胞和ADA,可作为高龄AECOPD患者病情监测和预后判断的有效观测指标。
Objective To analyze the changes of C-reactive protein (CRP) and pre-serum albumin (PA) before and after the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in elderly patients, and to explore its significance in the monitoring and prognosis of advanced AECOPD. Methods Sixty-five elderly patients (aged ≥80 years) were enrolled in this study. The changes of body temperature, serum leukocyte count (WBC), neutrophils, CRP, PA and adenosine deaminase (ADA) were measured before and after treatment. Results Serum levels of CRP were significantly increased in aged AECOPD patients, and the level of PA was significantly decreased. After treatment, CRP level was significantly lower (P <0.01) and PA level was significantly higher (P <0.01). Before and after treatment T, leukocyte, neutrophil and ADA levels did not change significantly, the difference was not statistically significant (P> 0.05). Conclusion Serum levels of CRP and PA in elderly patients with AECOPD have obvious changes after effective anti-infective therapy, and their sensitivity is better than that of body temperature, leucocyte, neutrophil and ADA, which can be used as effective observation indicators for the prognosis of AECOPD patients.