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目的探讨调强放射治疗配合化疗治疗晚期胰腺癌的临床效果。方法选取2013年1月至2014年12月间收治的56例晚期胰腺癌患者,采用简单随机抽样法分为观察组和对照组,每组28例。两组患者均给予吉西他滨化疗,观察组患者在此基础上加用调强放射治疗。比较两组患者的治疗有效率、不良反应发生率和生存率。结果观察组患者治疗有效率显著高于对照组,差异有统计学意义(P<0.05)。观察组患者无进展生存时间和总生存时间均高于对照组,差异均有统计学意义(均P<0.05)。观察组患者不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论调强放射治疗配合化疗治疗晚期胰腺癌临床疗效显著,可以有效地增加患者的生存时间,具有临床应用价值。
Objective To investigate the clinical effect of intensity modulated radiation therapy combined with chemotherapy in the treatment of advanced pancreatic cancer. Methods Fifty-six patients with advanced pancreatic cancer who were admitted between January 2013 and December 2014 were randomly divided into observation group and control group, with 28 cases in each group. Gemcitabine chemotherapy was administered to both groups, and patients in the observation group received IMRT on this basis. The treatment efficiency, adverse reaction rate and survival rate were compared between the two groups. Results The observation group patients treatment efficiency was significantly higher than the control group, the difference was statistically significant (P <0.05). The progression-free survival time and total survival time in observation group were significantly higher than those in control group (all P <0.05). The incidence of adverse reactions in the observation group compared with the control group, the difference was not statistically significant (P> 0.05). Conclusion IMRT combined with chemotherapy in the treatment of advanced pancreatic cancer has a significant clinical effect, which can effectively increase the survival time of patients and has clinical value.