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目的探讨胚胎染色体异常与流产之间的关系。方法收集常规流产患者人流手术清宫后的无菌绒毛组织及药流后的绒毛组织,共89例,采用培养法对其进行染色体分析。结果流产绒毛组织共89例(成功培养85例)进行染色体分析,异常核型49例,异常率为57%;其中染色体数目异常38例;染色体结构异常11例。结论染色体异常是流产的重要原因,胚胎绒毛染色体的分析,对于了解流产发生的原因以及指导下一次正常怀孕有着非常重要的意义。
Objective To investigate the relationship between embryonic chromosomal abnormalities and abortion. Methods Totally 89 cases of absent chorionic villi and abortion tissues after conventional abortion were collected, and their chromosomes were analyzed by culture method. Results Totally 89 cases of abortion (85 cases were successfully cultured) were analyzed by chromosome. There were 49 cases with abnormal karyotype, the abnormal rate was 57%. There were 38 cases with abnormal chromosome number and 11 cases with abnormal chromosomal structure. Conclusion Chromosomal abnormalities are the major causes of miscarriage. The analysis of embryonic chorion chromosomes is very important for understanding the causes of miscarriage and guiding the next normal pregnancy.