论文部分内容阅读
肝昏迷是严重肝衰竭的主要表现,预后很差,病死率极高,其发病机制十分复杂。随着对肝昏迷起因的深入研究:1971年Fischer提出“假性神经传递介质学说”,认为肝昏迷的发生可能是由于血液和大脑中氨基酸浓度的变化与平衡失调所致,其中尤其是支链氨基酸与芳香氨基酸的比例失调,从而引起中枢神经传递介质的代谢紊乱。如果采用输注普通的复方氨基酸输液,不仅不能纠正氨基酸谱的紊乱,相反会诱发和加重肝昏迷症状。为了探索含高支链氨基酸输液对肝性脑症治疗效果和临床反应,上海医药工业研究院、上海长征制药厂与上海第二医学
Hepatic coma is a major manifestation of severe liver failure, the prognosis is poor, high mortality, the pathogenesis is very complicated. With the in-depth study on the causes of hepatic coma, Fischer proposed the theory of “pseudo-neurotransmitter” in 1971 that hepatic coma may be caused by the change of amino acid concentration in the blood and brain and the imbalanced balance, especially among them Amino acids and aromatic amino acid imbalance, resulting in metabolic disorders of the central nervous system. If the infusion of common compound amino acid infusion, not only can not correct the disorder of the amino acid spectrum, on the contrary will induce and aggravate hepatic coma symptoms. In order to explore the effect of high-branched-chain amino acid infusion on hepatic encephalopathy and clinical response, Shanghai Institute of Pharmaceutical Industry, Shanghai Changzheng Pharmaceutical Factory and Shanghai Second Medical