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目的:对中药所致ADR较广泛了解,确切评估中药ADR趋势。方法:收集《中国药学文摘》(1990～1999年)和《药物不良反应文献题录》(1980～1989年)报道的有关中药ADR的病例,除外滥用、误用、中毒的病例调查分析。结果:共收集个案报道2732例有关中药不良反应,其中1980～1989年280例,1990～1999年2452例。结论:中药所致ADR以过敏反应为主,尤以中药针剂发生频率最高,这对制药工业与用药者均是一个启示,应找出原因,采取防范措施,保证人民用药安全有效。
OBJECTIVE: To understand ADR caused by traditional Chinese medicine more widely and evaluate the trend of ADR. Methods: The cases of ADR reported in Chinese Medical Abstracts (1990-1999) and Bibliographic References of Adverse Drug Reactions (1980-1989) were collected and analyzed. Cases of abuse, misuse and poisoning were collected. Results: A total of 2732 cases were collected to report the adverse reactions of traditional Chinese medicine, including 280 cases from 1980 to 1989 and 2452 cases from 1990 to 1999. Conclusion: ADR caused by traditional Chinese medicine is mainly anaphylaxis, especially the highest incidence of Chinese medicine injection, which is a revelation for the pharmaceutical industry and drug users. We should find out the reasons and take preventive measures to ensure the safety and effectiveness of drug use.