过去对滴眼剂大多考虑药物的稳定性、pH 值、渗透压等制剂学方面的问题,近来也十分注意到它的无刺激性、无菌操作制备和防止微生物污染方法等,然而首要的条件乃是滴眼药物在眼内被吸收并到达病灶部位。影响滴眼剂治疗效果的因素是:(1)在泪液中药物的浓度;(2)药物向眼内的透过性;(3)药物自眼内的消除速度;(4)在眼内组织 In the past, the ophthalmic preparations were mostly concerned with pharmaceutical formulation such as stability, pH value, and osmotic pressure. Recently, preparations for non-irritation, aseptic preparation, and prevention of microbial contamination have also been noted. However, the most important conditions But eye drops are absorbed in the eye and reach the lesion site. The factors that influence the efficacy of eye drops are: (1) the concentration of the drug in the tear; (2) the permeability of the drug into the eye; (3) the rate of elimination of the drug from the eye; (4)