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目的本研究在排除了其他潜在的精神并存症的基础上,综合性评价稳定型冠心病(CHD)患者重性抑郁症(MDD)发病情况,并考察其与心脏生物标志物如C反应蛋白(CRP)、肌钙蛋白T(TnT)以及氨基末端前B型脑钠素(NT-proBNP)水平的关系。方法横向考察72例稳定型CHD患者(30例患MDD,42例无精神疾病)。精神病学诊断标准依照中国精神疾病诊断标准CCMD-II-R,以CRP、TnT和NT-proBNP作为因变量,MDD、人口统计特征及地区医疗条件为恒变量进行回归分析。结果多元逐次回归分析显示,CRP水平与MDD有显著相关性(r=0.262,P=0.02),而与其他恒变量如人口统计学特征及医疗水平无关。另外研究结果表明Ⅱ型糖尿病与TnT(r=0.267,P=0.02)、年龄与NT-proBNP(r=0.374,P=0.001)之间亦有显著相关性。结论稳定型冠心病患者患重性抑郁症几率与CRP水平增高密切相关。
OBJECTIVE: This study evaluated the incidence of major depression (MDD) in patients with stable coronary heart disease (CHD) based on the exclusion of other underlying coexisting disorders and examined the association with cardiac biomarkers such as C-reactive protein CRP), troponin T (TnT), and N-terminal pro-B-type brain natriuretic peptide (NT-proBNP) levels. Methods A total of 72 patients with stable CHD (30 with MDD and 42 without psychosis) were studied laterally. The diagnostic criteria for psychiatry were based on the Chinese diagnostic criteria for mental illness CCMD-II-R. Regression analysis was performed with constant variables CVD, demographic characteristics and regional medical conditions using CRP, TnT and NT-proBNP as dependent variables. Results Multiple regression analysis showed that there was a significant correlation between CRP level and MDD (r = 0.262, P = 0.02), but not with other constant variables such as demographic characteristics and medical level. In addition, the results showed that there was a significant correlation between type 2 diabetes and TnT (r = 0.267, P = 0.02), age and NT-proBNP (r = 0.374, P = 0.001). Conclusion The prevalence of major depression in patients with stable coronary heart disease is closely related to the increased CRP level.