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本文观察了硫氮酮(DT)135-240mg对21例缺血性心衰的疗效及其对肾素-血管紧张素和交感-肾上腺系统的影响,结果表明:DT显著改善患者的临床体征和PEP/LVET,显著增加运动耐量和心脏指数,延迟运动诱发心绞痛。心功能改善在有心肌缺血证据者更明显。DT增加尿中去甲肾上腺素排出量,不影响血浆肾素活性和皿管紧张素Ⅱ含量。提示:DT能改善心肌梗塞后轻、中度心衰患者的心功能,特别适用于有心肌缺血证据者。
This article investigates the effects of 135-240 mg of DT on 21 patients with ischemic heart failure and their effects on renin-angiotensin and sympathetic-adrenal system. The results show that DT significantly improves clinical signs And PEP / LVET, significantly increased exercise tolerance and cardiac index, delayed exercise-induced angina. Improved cardiac function in patients with evidence of myocardial ischemia was more obvious. DT increased norepinephrine urinary excretion, does not affect plasma renin activity and methotrexate II content. Tip: DT can improve heart function in patients with mild and moderate heart failure after myocardial infarction, especially for those with evidence of myocardial ischemia.