混合配体化合物分子内配体间的疏水缔合作用首次发现于1974年,由于生物配体分子常常含有不参与配位的疏水基团,它们在这些生物配体的生理作用中起着重要的作用,羧肽酶A结构中的疏水袋在催化底物肽链C-末端肽键水解中的作用是一个很好的例证,因此对混合配合物分子内的配体间疏水缔合作用的研究越来越受到重视,目前已被确认为配合物 Hydrophobic association between intramolecular ligands of mixed ligand compounds was first discovered in 1974. Since biologic ligand molecules often contain hydrophobic groups that do not participate in coordination, they play an important role in the physiological roles of these biological ligands , The role of hydrophobic pocket in the carboxypeptidase A structure in the hydrolysis of the C-terminal peptide bond in the catalytic substrate peptide chain is a good illustration, therefore, the study on the hydrophobic association between the ligands in the molecule of the mixed peptide More and more attention has been confirmed as a complex