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目的:通过回顾分析2001～2008年该院出生缺陷的情况,了解该地区出生缺陷的高危高发因素,及时发现可疑的致畸因素及产前诊断的不足和需要强化之处,为开展出生缺陷的预防、早期诊断及干预提供依据。方法:依据《中国出生缺陷监测方案》,对2001～2008年在该院分娩的产妇及其围产儿的资料进行统计和分析。结果:8年共监测围产儿20 394例,缺陷儿138例,发生率为6.77‰。主要缺陷为总唇裂、指(趾)畸形(多/并指趾)、复合畸形、无脑畸形、肾脏异常、先天性脑积水、先天性心脏病、肢体短缩;产母年龄<20岁和年龄≥35岁出生缺陷率的危险性明显增加。结论:孕前及孕早期预防、孕期宣教、积极开展产前诊断,加强围产期保健,提高监测质量,可以减少围产儿出生缺陷的发生。
OBJECTIVE: To retrospectively analyze the incidence of birth defects in this hospital from 2001 to 2008, to find out the high risk and high risk factors of birth defects in this area, to detect suspicious teratogenic factors and the deficiency of prenatal diagnosis in time, Prevention, early diagnosis and intervention provide the basis. Methods: Based on “China Birth Defects Monitoring Program”, the data of maternal and perinatal delivery in this hospital from 2001 to 2008 were statistically analyzed. Results: In the past 8 years, 20 394 perinatal infants and 138 defective infants were monitored. The incidence was 6.77 ‰. The main defects were total cleft lip, digit deformity (multiple / double digits), composite deformity, anencephaly, renal abnormalities, congenital hydrocephalus, congenital heart disease and limb shortening; mother’s age <20 years And the risk of birth defects rate ≥35 years old significantly increased. Conclusion: Pre-pregnancy and early pregnancy prevention, prenatal education, and actively carry out prenatal diagnosis, strengthen perinatal care and improve the quality of monitoring, can reduce the incidence of perinatal birth defects.