本研究应用原位杂交技术检测人正常胚胎及葡萄胎绒毛中纤蛋白溶酶原激活与抑制因子（ｔＰＡ，ｕＰＡ，ＰＡＩ－１）及其尿激酶受体（ｕＰＡ－Ｒ）的表达。结果表明，人正常胚胎绒毛的合体滋养层和细胞滋养层细胞中均含有ｔＰＡ、ｕＰＡ、ＰＡＩ－１及ｕＰＡ－ＲｍＲＮＡ，葡萄胎绒毛中ｔＰＡ、ＰＡＩ－１及ｕＰＡ－ＲｍＲＮＡ表达明显增强。提示：（１）ＰＡ－ＰＡＩ的协同作用在维持妊娠期间正常的纤蛋白溶解可能是重要的；（２）纤溶激活与抑制在葡萄胎的发展过程中可能起作用 In this study, in situ hybridization was used to detect the expression of tPA, uPA and PAI-1 and uPA-R in human normal embryos and hydatidiform mole. The results showed that both tPA, uPA, PAI-1 and uPA-RmRNA were present in syncytiotrophoblast and trophoblast cells of human normal embryo villus. The expression of tPA, PAI-1 and uPA-RmRNA in trophoblast were significantly increased. Tip: (1) Synergy of PA-PAI may be important in maintaining normal fibrinolysis during pregnancy; (2) Fibrinolysis and inhibition may play a role in the development of hydatidiform moles