作者根据细胞配体间的共价化学反应,试验了增强免疫原性的新途径。大多数免疫应答中的主要过程是诱导抗原提呈细胞(APC)与辅助性T细胞(TH)间的相互作用。在化学水平上,细胞表面配体间暂时的羰基-氨基缩合反应对抗原特异性T细胞活化也是必需的,这种反应可通过提高反应性配体 The authors tested new ways to enhance immunogenicity based on the covalent chemistry between cellular ligands. The major process in most immune responses is the induction of the interaction between antigen presenting cells (APCs) and helper T cells (TH). Chemically, temporary carbonyl-amino condensation reactions between cell-surface ligands are also required for antigen-specific T cell activation, which can be accomplished by increasing the number of reactive ligands