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目的探讨生殖激素LH、FSH、E2、T与染色体异常及精子密度之间的关系。方法对我中心收集的男性不育患者199例,采用化学发光免疫分析仪检测血清LH、FSH、E2和T;外周血淋巴细胞染色体核型分析;全自动精子分析仪进行精液分析,分组比较。结果非梗阻性无精子症患者与各组比较有显著差异,精子密度正常、少精子症、梗阻性无精子症患者之间血清FSH、LH、T水平无明显差异;与染色体正常精子密度正常组比较,性染色体畸变组LH和FSH水平显著升高,常染色体畸变和Y染色体微缺失患者激素水平无明显差异。结论生殖激素水平与性染色体畸变、精子密度有一定的相关性,激素测定对睾丸生精功能的判断有指导意义。
Objective To investigate the relationship between reproductive hormones LH, FSH, E2, T and chromosomal abnormalities and sperm density. Methods 199 infertile male patients were collected from our center. Serum LH, FSH, E2 and T were detected by chemiluminescence immunoassay. Chromosome karyotype analysis of peripheral blood lymphocytes. Semen analysis was performed by automatic sperm analyzer. Results There was significant difference between the groups of non-obstructive azoospermia and normal control group. There was no significant difference in serum FSH, LH and T between patients with oligospermia and obstructive azoospermia. In comparison, the levels of LH and FSH in sex chromosome aberration group were significantly increased. There was no significant difference in the level of hormones between patients with autosomal aberration and Y chromosome microdeletion. Conclusion The level of reproductive hormones has some correlation with sex chromosome aberration and sperm density. The determination of hormones has instructive significance for the testicular spermatogenic function.