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目的探讨多囊卵巢综合征(PCOS)患者代谢综合征(MetS)及其组分的发生特点,评估MetS组分对PCOS患者罹患MetS发生风险的预测能力。方法选择2008年9月至2012年4月在福建省妇幼保健院妇科门诊诊断为PCOS患者208例及随机招募的体检者205例。PCOS诊断标准参照鹿特丹标准,MetS诊断标准依据国际糖尿病联盟(IDF)颁布的定义。所有受试者均进行人体测量和生化指标测定,比较两组MetS及其组分的发生特点,筛选对PCOS患者罹患MetS发生风险的预测指标。结果 208例PCOS患者MetS发生率为21.15%,明显高于对照组3.41%。具有1项及以上MetS组成成分的PCOS患者高达69.23%;血脂异常是主要的代谢紊乱,其次是高血压、空腹血糖异常。腰围(WC)结合高密度脂蛋白胆固醇(HDL-C)或腰围(WC)结合三酰甘油(TG)具有对PCOS患者发生MetS风险较高的预测能力。结论对于WC≥80cm的PCOS患者,一旦具备HDL-C<1.29mmol/L或TG>1.7mmol/L就应对其进行预防MetS发生的早期干预。
Objective To investigate the occurrence of metabolic syndrome (MetS) and its components in patients with polycystic ovary syndrome (PCOS) and to evaluate the predictive ability of MetS components in the risk of developing MetS in PCOS patients. Methods From September 2008 to April 2012, 208 cases of PCOS diagnosed in gynecology outpatient department of Fujian Provincial Maternal and Child Health Hospital and 205 cases randomly recruited were collected. PCOS diagnostic criteria refer to the Rotterdam standard, MetS diagnostic criteria according to the International Diabetes Federation (IDF) promulgated the definition. All subjects were measured by human body and biochemical indicators, MetS and its components were compared between two groups to screen the prognosis of patients with PCOS risk of MetS. Results 208 cases of PCOS patients with MetS incidence was 21.15%, significantly higher than the control group 3.41%. PCOS patients with one or more MetS components were as high as 69.23%; dyslipidemia was the major metabolic disorder followed by hypertension and impaired fasting glucose. Waist circumference (WC) combined with high-density lipoprotein cholesterol (HDL-C) or waist circumference (WC) with triglyceride (TG) has a high predictive value of MetS risk in PCOS patients. Conclusions For PCOS patients with WC ≥ 80 cm, early intervention for prevention of MetS should be performed once HDL-C <1.29 mmol / L or TG> 1.7 mmol / L.