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目的比较复方连芩双层缓释药膜与金莲清热泡腾片对手足口病患儿血清及免疫水平的影响。方法将200例手足口病患儿随机分为试验组和对照组各100例。在常规方法治疗的基础上,试验组给予复方连芩双层缓释药膜与金莲清热泡腾片治疗,对照组给予金莲清热泡腾片治疗。分别检测2组患者治疗前后血清心肌酶、肌钙蛋白、CD+3、CD+3CD+4、CD+3CD+8水平。结果2组治疗后血清CK-MB、c Tn I水平显著低于治疗前,血清CD+3、CD+3CD+4、CD+3CD+8水平高于治疗前,且试验组变化幅度大于对照组,差异均有统计学意义(P<0.05)。结论复方连芩双层缓释药膜联合常规方法治疗小儿手足口病能降低血清CK-MB、c Tn I水平,同时能提高血清CD+3、CD+3CD+4、CD+3CD+8水平,优于金莲清热泡腾片。
Objective To compare the effects of Lianqian Lianqin double-coated sustained-release film and Jinlian chongqing effervescent tablet on serum and immune status in children with hand-foot-mouth disease. Methods 200 cases of hand, foot and mouth disease were randomly divided into experimental group and control group of 100 cases. On the basis of conventional treatment, the experimental group was treated with double-layer sustained-release compound Ligustrazine and Jinlian Qingre effervescent tablets, while the control group was treated with Jinlian Qingre effervescent tablets. The levels of serum myocardial enzymes, troponin, CD + 3, CD + 3CD + 4 and CD + 3CD + 8 were measured before and after treatment in two groups. Results Serum levels of CK-MB and cTnI in the two groups were significantly lower than those before treatment, and the levels of serum CD + 3, CD + 3CD + 4 and CD + 3CD + 8 were higher than those before treatment, and the changes in the experimental group were greater than those in the control group , The differences were statistically significant (P <0.05). Conclusion The combination of double-coated sustained-release film of Lianqian Lianqin and conventional method for the treatment of hand-foot-mouth disease in children can decrease the levels of serum CK-MB and cTnI and increase the levels of serum CD + 3, CD + 3CD + 4 and CD + 3CD + 8 , Better than the lotus heat effervescent tablets.