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目的探讨薯莨鞣质和五倍子鞣质对辐射损伤的防护作用。方法 40只雄性昆明种小鼠,随机分为空白对照组、单纯照射组、茶多酚组(阳性对照组)、五倍子鞣质组和薯莨鞣质组。给予单次8.0 Gy 60Coγ射线照射(剂量率2.0 Gy/min),照前2h及照后18h分别各灌胃给药一次,测定30d存活率、平均存活时间及保护系数等,空白对照组佯照射。结果单纯照射组小鼠照后16d内全部死亡,平均存活时间(12.0±2.45)d。薯莨鞣质组、五倍子鞣质组和茶多酚组小鼠的平均存活时间分别为(26.25±7.13)d(、21.88±8.89)d和(23.25±9.33)d,与单纯照射组相比生存时间明显延长(P<0.01或P<0.05)。结论薯莨鞣质和五倍子鞣质可提高8.0 Gy 60Coγ射线照射小鼠30天存活率,对γ射线辐射损伤具有防护作用。
Objective To investigate the protective effect of the tannin and gallic tannin on radiation injury. Methods Forty male Kunming mice were randomly divided into blank control group, irradiation group, tea polyphenols group (positive control group), gallnut tannin group and diosgenin group. A single administration of 8.0 Gy 60Coγ ray (dose rate of 2.0 Gy / min), 2 h before irradiation and 18 h after irradiation were administered intragastrically to determine the 30-day survival rate, mean survival time, and protection coefficient. The blank control group . Results The mice in the irradiation group died completely within 16 days after irradiation, with a mean survival time of (12.0 ± 2.45) d. The mean survival time of the mice treated with the methods of treating the diseases of the genital tangerine, gallnut tannin and tea polyphenols were (26.25 ± 7.13) days (21.88 ± 8.89) days and (23.25 ± 9.33 days), respectively Survival time was significantly longer (P <0.01 or P <0.05). Conclusion Diostem tannin and Galla chinensis could increase the 30-day survival rate of 8.0 Gy 60Co γ-ray irradiated mice, and have a protective effect on γ-ray radiation damage.