免疫耐受性一般在胚胎期和新生初期动物较易造成,但用异种蛋白造成成年动物免疫耐受性的实验研究,近年来也陆续有所报道。我们最近用正常大鼠血清给成年绵羊一次大剂量静脉内注射,也造成了免疫耐受性。 材料与方法 (一)实验动物 1.成年雄性绵羊10头,体重30～47公 Immunotolerance is generally more likely to be caused by animals in the embryonic and early neonatal period. However, experimental studies on the immune tolerance of adult animals using heterologous proteins have been reported in recent years. We recently used a normal rat serum to give a large dose of intravenous injection to adult sheep, which also caused immune tolerance. Materials and Methods (1) Experimental animals 1. Adult male sheep 10, weighing 30 to 47 males