论文部分内容阅读
目的:采用剂量反应Meta分析分别对25-羟维生素D[25-hydroxyvitamin D,25(OH)D]水平、甲状旁腺素(parathyroid hormone,PTH)水平与高血压发病风险进行综合评价。方法:全面检索Pub Med、Embase、CBM、CNKI和VIP数据库,纳入25(OH)D、PTH与高血压发病风险的前瞻性研究,检索时限均为建库至2016年8月。采用剂量反应模型对25(OH)D、PTH与高血压发病风险进行拟合,采用Stata13.0进行Meta分析。结果:共纳入9项前瞻性研究,研究对象为西方人群,样本含量25 658人。线性剂量反应Meta分析结果显示,25(OH)D每增加25 nmol/L,高血压的发病风险下降7%(RR=0.93,95%CI=0.89~0.97,P=0.000);而PTH每增加15 pg/m L,高血压的发病风险增加6%(RR=1.06,95%CI=1.02~1.10,P=0.001)。结论:针对西方人群,随着25(OH)D水平的降低或PTH水平的升高,可能导致高血压发病风险的增加。这给亚洲人群高血压的预防提供了重要线索。
OBJECTIVE: To evaluate the level of 25-hydroxyvitamin D (25 (OH) D], the level of parathyroid hormone (PTH) and the risk of developing hypertension by dose-response meta-analysis. Methods: A prospective study of PubMed, Embase, CBM, CNKI and VIP databases was conducted to enumerate the risk of 25 (OH) D, PTH and hypertension. The search time was from the database to August 2016. The dose-response model was used to fit the risk of 25 (OH) D, PTH and hypertension, and Meta-analysis was performed using Stata13.0. Results: A total of 9 prospective studies were included in the study. The study population was Western, with 25 658 samples. The linearized dose-response meta-analysis showed that for each 25 nmol / L increase in 25 (OH) D, the risk of hypertension was reduced by 7% (RR = 0.93, 95% CI = 0.89-0.97, P = 0.000) 15 pg / m L, the risk of hypertension increased by 6% (RR = 1.06, 95% CI = 1.02-1.10, P = 0.001). CONCLUSIONS: With a decrease in 25 (OH) D levels or elevated PTH levels in western populations, this may lead to an increased risk of developing hypertension. This provides important clues to the prevention of hypertension in Asian populations.