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现有证据说明接触一些微量金属能明显改变宿主防御机制的功能。本文研究了与可吸入颗粒有关的工业和环境污染物镉(Cd)、铬(Cr)和镍(Ni)对机体初次体液免疫系统的影响。实验选用6周龄、体重为20～25g的无特殊病原小鼠。分别肌肉注射NiSO_4、NiCl_2、NiO、CdCl_2和CrCl_3溶液或吸入NiCl_2和CdCl_2气溶胶。在吸入气溶胶后2小时或肌肉注射后立即给予腹腔注射绵羊红细胞0.5ml(4.5～5×10~8个/ml)免疫。自次日算起的第四天用直接溶血空斑试验测定实验与对照小鼠脾脏细
The available evidence shows that exposure to some trace metals can significantly alter the function of host defense mechanisms. This article studies the effects of industrial and environmental pollutants such as cadmium (Cd), chromium (Cr) and nickel (Ni) associated with inhalable particles on the body’s first humoral immune system. Experimental selection of 6 weeks old, weighing 20 ~ 25g no special pathogenic mice. NiSO 4, NiCl 2, NiO, CdCl 2 and CrCl 3 solutions were injected intramuscularly or inhaled NiCl 2 and CdCl 2 aerosols respectively. Sheep red blood cells were intraperitoneally injected with 0.5 ml (4.5-5x10-8 cells / ml) 2 hours after inhalation of aerosol or immediately after intramuscular injection. On the fourth day from the next day, the direct hemolytic plaque assay was used to determine the spleen fineness