本文以膀胱癌为重点,试将目前尿路肿瘤抗原对判定肿瘤恶性度的意义综述如下。膀胱肿瘤具有多中心、易复发的特点,多无症状地进展,故以尽量早期诊断行保留膀胱的治疗为宜,Chopin等对人膀胱癌通过杂交细胞癌制作G_4和E_7两种单克隆抗体,并叙述了该抗体在免疫组织学上与含上皮内癌的低分化膀胱肿瘤及部分表浅性高分化膀胱肿瘤的反应。4例膀胱肿瘤在膀胱全切术后立即将这些抗体注入瘤体内,离体进行免疫组织学研究。通过对肿瘤的特异染色研究,将这些抗体与荧光色素同时注入体内,可发现上皮内癌类肉眼难以发现的非乳头状癌,有并用抗体与抗癌药治疗肿瘤的可能性。作者就目前对膀胱肿瘤可能有价值的TPA进行 This article focuses on bladder cancer, and summarizes the significance of current urinary tract tumor antigens in determining the degree of malignancy. Bladder neoplasms are multi-centered, easily recurring, and often progress asymptomatically. Therefore, it is advisable to perform early bladder cancer treatment as early as possible. Chopin et al. used G9 and E7 monoclonal antibodies against human bladder cancer to produce hybrid bladder cancer cells. The reaction of the antibody to poorly differentiated bladder tumors and partially superficially well-differentiated bladder tumors containing intraepithelial neoplasia was immunohistologically described. Four of the bladder tumors were injected into the tumor immediately after total cystectomy and immunohistochemical studies were performed in vitro. Through the study of the specific staining of tumors, these antibodies and fluorescent pigments are injected into the body at the same time, and non-papillary cancers hardly visible to the naked eye in intraepithelial cancers can be found, and there is a possibility of using antibodies and anticancer drugs together to treat tumors. Authors on current TPA that may be valuable for bladder cancer