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目的 探讨 β-内啡肽在缺血性脑损伤中的作用机制。方法 应用放射免疫分析法对 46例急性脑梗塞患者血浆β-内啡肽 (β- EP)及血清丙二醛 (MDA)、超氧化物歧化酶 (SOD)含量进行测定。结果 梗塞急性期 β- EP及 MDA、SOD含量均显著升高 (P <0 .0 1 ) ,病情越重 ,含量越高 ;而且血浆β- EP与 MDA含量呈显著正相关 (P <0 .0 1 ) ,β- EP与 SOD含量 ,在轻型病人相关性不明显 ,在中型和重型病人呈显著正相关 (P <0 .0 1 ,P <0 .0 5)。结论 内源性阿片肽和自由基在缺血性脑损伤中具有重要的作用 ,且内源性阿片肽与自由基的产生有一定的相关关系
Objective To investigate the mechanism of β-endorphin in ischemic brain injury. Methods The levels of β-endorphin (β-EP), serum malondialdehyde (MDA) and superoxide dismutase (SOD) in 46 patients with acute cerebral infarction were measured by radioimmunoassay. Results The levels of β-EP, MDA and SOD were significantly increased in the acute stage of infarction (P <0.01). The more serious the disease was, the higher the content of β-EP, MDA and the content of β-EP in plasma were positively correlated. 0 1). There was no significant correlation between β-EP and SOD in light-weight patients, and significant positive correlation between medium and heavy-weight patients (P <0.01, P <0.05). Conclusions Endogenous opioid peptides and free radicals play an important role in ischemic brain injury and there is a correlation between endogenous opioid peptides and free radicals