The prime objective of the present communication is to examine the entropy-optimized second order velocity slip Darcy–Forchheimer hybrid nanofluid flow of viscous material between two rotating disks. Electrical conducting flow is considered and saturated through Darcy–Forchheimer relation. Both the disks are rotating with different angular frequencies and stretches with different rates. Here graphene oxide and titanium dioxide are considered for hybrid nanoparticles and water as a continuous phase liquid. Joule heat-ing, heat generation/absorption and viscous dissipation effects are incorporated in the mathematical mod-eling of energy expression. Furthermore, binary chemical reaction with activation energy is considered. The total entropy rate is calculated in the presence of heat transfer irreversibility,fluid friction irreversibility, Joule heating irreversibility, porosity irreversibility and chemical reaction irreversibility through thermo-dynamics second law. The nonlinear governing equations are first converted into ordinary differential equations through implementation of appropriate similarity transformations and then numerical solutions are calculated through Built-in-Shooting method. Characteristics of sundry flow variables on the entropy generation rate, velocity, concentration, Bejan number, temperature are discussed graphically for both gra-phene oxide and titanium dioxide hybrid nanoparticles. The engineering interest like skin friction coeffi-cient and Nusselt number are computed numerically and presented through tables. It is noticed from the obtained results that entropy generation rate and Bejan number have similar effects versus diffusion param-eter. Also entropy generation rate is more against the higher Brinkman number.