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目的研究雷公藤内酯醇贴剂的抗炎、镇痛作用。方法通过小鼠耳廓肿胀、毛细血管通透性、肉芽肿以及大鼠角叉菜胶致炎实验,观察贴剂的抗炎效果;通过热板法、扭体法和电刺激法,观察贴剂的镇痛效果。结果贴剂在雷公藤内酯醇含量为3.72,7.44,14.88 mg·m?2内能有效抑制由二甲苯诱发的小鼠耳廓肿胀、腹部皮肤毛细血管通透性增高现象,抑制纸片引起小鼠肉芽组织增生以及角叉菜胶致大鼠足趾肿胀;并对醋酸所致小鼠腹痛扭体有抑制作用,提高鼠尾电刺激痛阈值。结论雷公藤内酯醇贴剂对急、慢性炎症有良好抑制作用,对化学性刺激有一定镇痛效果。
Objective To study the anti-inflammatory and analgesic effect of triptolide patch. Methods Anti-inflammatory effects of the patch were observed by mouse ear auricle swelling, capillary permeability, granuloma and rat carrageenan-induced inflammation. The anti-inflammatory effects of the patch were observed by hot plate method, writhing method and electrical stimulation method Agent analgesic effect. Results The patch in the triptolide content of 3.72,7.44,14.88 mg · m 2 can effectively inhibit xylene-induced mouse ear swelling, increased skin permeability of the skin of the abdomen phenomenon, inhibit the paper caused small Mouse granulation tissue hyperplasia and carrageenan caused by rat toe swelling; and acetic acid induced writhing in mice with abdominal pain inhibit the increase of rat tail electric stimulation pain threshold. Conclusion Triptolide patch has a good inhibitory effect on acute and chronic inflammation, and has certain analgesic effect on chemical stimulation.