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山莨菪碱抑制巨噬细胞受佛波酯PMA和钙离子载体A_(23187)刺激时的前列腺素合成,经山茛菪碱预先温育,细胞的前列腺素合成也明显减少。山莨菪碱对外源性花生四烯酸刺激的前列腺素合成无抑制作用。结果提示山莨菪碱作用发生在磷脂酶A_2水平。
Anisodamine inhibits prostaglandin synthesis when macrophages are stimulated by phorbol ester PMA and calcium ionophore A 23187, and preincubation with anisodamine results in a significant reduction of prostaglandin synthesis. Anisodamine has no inhibitory effect on prostaglandin synthesis stimulated by exogenous arachidonic acid. The results suggest that the effect of anisodamine occurs at phospholipase A2 level.