目的:探讨运脾和络颗粒对糖尿病周围神经病变大鼠血浆β-内啡肽的影响。方法:造模大鼠随机分成正常组、模型组、运脾和络颗粒高、中、低剂量组、甲钴胺组,用酶联免疫法检测运脾和络颗粒对糖尿病周围神经大鼠血浆β-内啡肽的影响。结果:运脾和络颗粒高、中剂量组能明显上调大鼠血浆β-内啡肽(P<0.05)。结论:运脾和络颗粒能上调糖尿病周围神经病变大鼠血浆β-内啡肽,可能是其改善糖尿病周围神经病变的机理之一。 Objective: To investigate the effects of Yunpi Heluo Granules on plasma β-endorphin in diabetic peripheral neuropathy rats. Methods: The model rats were randomly divided into normal group, model group, Yunpi group and Luohuang group high, medium and low dose group, mecobalamine group, and the effect of Yunpi Heluo Granule on plasma of diabetic peripheral nerve rats Effects of β-endorphin. Results: There was a significant increase in plasma β-endorphin (P <0.05) in rats with high and middle dose Yunpi group and Luohuo granules. Conclusion: Yunpi Heluo Granule can increase plasma β-endorphin in diabetic peripheral neuropathy rats, which may be one of the mechanisms to improve diabetic peripheral neuropathy.