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概 述 第一代吡啶酮酸类抗菌剂萘啶酸(Nati-dixic acid)于1963年投入临床使用,迄今已有二十多年的历史,此后又有西洛沙星(Cinozacin)和奥啉酸(Oxotinic acid)等陆续投入使用,对治疗尿路感染起过积极的作用。但由于抗菌谱较窄,易产生耐药性和毒副作用较多,因此限制了它们的广泛应用。七十年代初,日本推出吡哌酸(Pipemidic acid)等第二代抗菌剂,这类药物的抗菌谱较广、抗菌活性较强,加之在组织中浓度较大,故除尿路感染外还可用于其它感染的治疗。自
Overview The first generation of pyridone acid antibacterial agents, nati-dixic acid, has been in clinical use in 1963 and has been in use for more than two decades, followed by Cinozacin and Oral Acid (Oxotinic acid) have been put into use, the treatment of urinary tract infections played an active role. However, due to narrower antibacterial spectrum, easy to produce resistance and more side effects, thus limiting their widespread use. In the early seventies, Japan launched Pipemidic acid and other second-generation antimicrobial agents, such drugs broad antibacterial spectrum, strong antibacterial activity, combined with a greater concentration in the organization, it is also in addition to urinary tract infection Can be used for the treatment of other infections. from