最近十多年来,氨茶碱的疗效与毒性反应和血药浓度之间的相互关系已被阐明,随着茶碱血浓度监测技术的进展,对应用氨茶碱的安全性和有效性进一步受到重视。本文着重对氨茶碱作用与应用的新见解作一概述。【对“磷酸二酯酶抑制说”的异议】通常认为氨茶碱松弛支气管平滑肌的机制是抑制磷酸二酯酶的活性,减少cAMP水解,使细胞内cAMP水平升高。cAMP激活蛋白激 In the recent ten years, the correlation between the efficacy and toxicity of aminophylline and plasma concentration has been elucidated. With the progress of theophylline blood concentration monitoring technology, the safety and effectiveness of aminophylline application Received attention. This article focuses on the new insights into the action and use of aminophylline. Opposition to Phosphodiesterase Inhibition It is generally accepted that the mechanism by which aminophylline relaxes bronchial smooth muscle is inhibition of phosphodiesterase activity, reduction of cAMP hydrolysis, and elevation of intracellular cAMP levels. cAMP activator protein shock