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阿糖腺甙(Vidarabine)是一种嘌呤腺甙,在组织培养中能抑制某些DNA病毒的复制,并已试用于人的各种疱疹病毒感染。最近一篇报告认为,治疗单纯疱疹病毒脑炎显著降低病死率。因此,作者对其治疗乙型肝炎病毒感染的作用进行评价。 2例慢性活动性肝炎病人,近期肝活检异常,血清Dane颗粒DNA聚合酶(表示病毒颗粒复制的标志)水平很高。应用阿糖腺甙剂量为15mg/kg/日,9～14日为一疗程,共两个疗程;病人甲的两个疗程间隔7周,病人乙间隔20日。病人在治疗前不久、同时或以后均未接受其它治疗。结果:(1)DNA聚合酶活性:病人甲在两个疗程中迅速下降至接近O的水平,停药后即回升。病人乙在第一个疗程中酶活性下降至O,停药后至第二个疗程开始前未回升至治疗前
Vidarabine is a purine adenosine that inhibits the replication of certain DNA viruses in tissue culture and has been tested for human herpes simplex virus infections. According to a recent report, the treatment of herpes simplex virus encephalitis significantly reduced mortality. Therefore, the authors evaluated their role in the treatment of hepatitis B virus infection. Two patients with chronic active hepatitis, the recent liver biopsy abnormalities, serum Dane particulate DNA polymerase (virus particles that sign of replication) high level. Radix adenosine dose of 15mg / kg / day, 9 to 14 for a course of treatment, a total of two courses; patients A treatment interval of seven weeks, the patient B interval of 20 days. The patient did not receive any other treatment either shortly before, simultaneously with or after treatment. RESULTS: (1) DNA polymerase activity: Patient A rapidly decreased to near O level during two courses of treatment and recovered after withdrawal. Patient B in the first course of enzyme activity decreased to O, after stopping until the second course of treatment did not return to before treatment before treatment