论文部分内容阅读
C-erbB-2癌基因首先在化学物质诱发的小鼠神经母细胞瘤中被发现。这种基因编码一种分子量为185kD的透膜糖蛋白,它具有酪氨酸酶的活性已发现不同部位的腺癌中有C-erbB-2基因的扩增,该基因与乳腺癌的复发和转移有关。作者用免疫组织化学方法(ABC法)采用抗C-erbB-2蛋白抗体研究203例发生于肺的癌肿标本的石蜡切片。其中腺癌119例,鳞癌84例。病人年龄33～85岁(平均63岁),男163
The C-erbB-2 oncogene was first discovered in chemically induced mouse neuroblastoma. This gene encodes a 185 kD molecular weight transmembrane glycoprotein that has the activity of tyrosinase. It has been found that there are amplifications of the C-erbB-2 gene in adenocarcinomas at different sites. This gene is associated with breast cancer recurrence and Transfer related. The authors used immunohistochemical methods (ABC method) to use anti-C-erbB-2 protein antibody to study paraffin sections of 203 lung cancer specimens. There were 119 adenocarcinomas and 84 squamous cell carcinomas. The patient’s age is 33-85 years old (average 63 years old), male 163