论文部分内容阅读
作者曾报道PGI_2能抑制正常人离体子宫肌的自发运动,并且特别减弱由PGF_2α所致的子宫肌痉挛。其药理意义为:若孕期子宫能够产生PGI_2,可能在调节前列腺素的催产活性方面起作用。为了更确切的证明PGI_2的生理重要性,作者研究了子宫产生PGI_2的能力及PGI_2对子宫的松驰作用。取25～35岁经产妇的手术病人子宫标本。取用37℃含氧台氏液灌流其纵行子宫肌条,流速10毫升/分。加入不同浓度的PGI_2及其代谢产物6氧化前列腺素(6-oxo-PGF_1α),以观察对子宫肌的作用。取子宫肌条培养于无钙克氏液中(pH8.0)2和15分钟,每毫克组织用0.1毫升溶液。取混合培
The authors have reported that PGI_2 can inhibit the spontaneous movement of isolated uterine muscle in normal people, and in particular weakened the uterine muscle spasm caused by PGF_2α. Its pharmacological significance is: if the uterus during pregnancy can produce PGI_2, may play a role in the regulation of prostaglandin oxytocin activity. To confirm the physiological importance of PGI 2, the authors studied the ability of the uterus to produce PGI 2 and the relaxation effect of PGI 2 on the uterus. Take 25 to 35-year-old maternal surgical patient’s uterus specimens. Take 37 ℃ oxydation of Taiwan’s liquid peritoneal myometrial longitudinal, flow rate of 10 ml / min. Different concentrations of PGI_2 and its metabolite 6-oxo-PGF_1α were added to observe the effect on uterine muscle. Uterine strips were harvested in calcium-free Krebs (pH 8.0) for 2 and 15 minutes, using 0.1 ml of solution per milligram of tissue. Take mixed training