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目的探讨国产氯吡格雷在不稳定型心绞痛患者中的临床疗效。方法选2005年9月至2009年8月102例不稳定型心绞痛患者,随机分入常规口服药物治疗组(A组,51例)和国产氯吡格雷组(B组,51例)。B组在常规口服药物的基础上加国产氯吡格雷75 mg,1次/d,持续4周。在入组前以及服药每周内门诊随访,共4周,询问病史,不良反应以及行活动平板检查。结果102例患者全部完成随访。4周内,B组胸痛发作每周次数减少(4.2±0.5)次,而A组减少(2.1±0.8)次,两组相比有统计学差异(P<0.05)。硝酸甘油消耗量B组平均减少(6.1±0.7)片而A组平均减少(3.3±0.9)片(P<0.05)。运动平板运动持续时间B组增加(63.6±2.3)s而A组增加(31.6±2.2)s(P<0.05)。结论在传统药物治疗的基础上联用国产氯吡格雷,可以使不稳定型心绞痛患者受益,且安全性好。
Objective To investigate the clinical efficacy of domestic clopidogrel in patients with unstable angina pectoris. Methods A total of 102 patients with unstable angina pectoris from September 2005 to August 2009 were randomly assigned to conventional oral treatment group (group A, n = 51) and domestic clopidogrel group (group B, n = 51). Group B was given oral clopidogrel 75 mg once daily for 4 weeks. In the pre-enrollment and medication outpatient visits every week, a total of 4 weeks, asked about the history, adverse reactions, and activities of flat-panel test. Results All 102 patients were followed up. In 4 weeks, the frequency of chest pain in group B decreased 4.2 ± 0.5 times and in group A decreased 2.1 ± 0.8 times, there was significant difference between the two groups (P <0.05). The consumption of nitroglycerin decreased in group B (6.1 ± 0.7) and in group A (3.3 ± 0.9) on average (P <0.05). The duration of treadmill exercise increased in group B (63.6 ± 2.3) s and in group A (31.6 ± 2.2) s (P <0.05). Conclusion The combination of domestic clopidogrel on the basis of traditional drug therapy can benefit patients with unstable angina and have good safety.