应用脂类作为人工生物膜,制备脂质小泡(Vesicle)及脂质体(Liposome),是近几年来发展的新技术。国外已开始用以模拟细胞膜,研究细胞表面的结构和功能;包裹药物及生物活性分子,防止降解,增加细胞对药物的摄取,来提高疗效。去年,已有人开始尝试包裹RNA的巨脂质体(直径达1微米),这对于遗传工程,基因操纵亦具有潜在的意义。它将成为细胞生物学及分子生物学研究中的一项重要课题。国内虽亦有人设想发展脂质体的研究,然而迄今未见报告。上海市肿瘤研究所生化及分子生物学研究室,今年以来,开展了脂质小泡及脂质体包裹RNA的工作。一建立了一种新方法,国外目前常用的超声波振荡 Application of lipids as artificial biofilm for the preparation of vesicles and liposomes is a new technology developed in recent years. Foreign countries have begun to simulate the cell membrane, cell surface structure and function of research; package drugs and bioactive molecules, to prevent degradation, increase cellular uptake of drugs to improve the curative effect. Last year, giant liposomes (up to 1 micron in diameter) were wrapped around the RNA, which has potential implications for genetic engineering and genetic manipulation. It will be an important topic in the research of cell biology and molecular biology. Although some people in the country envisaged the development of liposomes, no reports have so far been reported. Shanghai Institute of Oncology Laboratory of Biochemistry and Molecular Biology, this year, carried out lipid vesicles and liposomes wrapped RNA work. A new method has been established, which is commonly used abroad for ultrasonic oscillation