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目的:探究参麦注射液与布地奈德联合治疗急性酒精中毒伴吸入性肺炎的临床疗效。方法:选择2012年6月~2015年6月期间,我院收治急性酒精中毒合并吸入性肺炎患者112例为研究对象,采用随机数字法将其随机分为观察组(57例)和对照组(55例)。对照组在基础治疗的基础上给予布地奈德治疗,观察组在对照组的基础上联合参麦注射液治疗,收集并分析治疗后两组患者症状恢复时间、症状消失时间、清醒后不良反应发生情况、治疗前后肝功能指标及血清炎性因子指标。结果:观察组患者清醒时间、血压恢复时间及头晕、头痛、电解质紊乱的发生率均显著低于对照组(P<0.05);治疗后两组患者间天冬氨酸氨基转移酶(AST)、丙氨酸转氨酶(ALT)、γ-谷氨酰基转移酶(GGT)水平均出现显著降低,且观察组均显著低于对照组(P<0.05);观察患者咳嗽消失、气喘缓解、哮鸣音消失及湿罗音消失时间均显著低于对照组(P<0.05);治疗后两组患者血清IL-6、TNF-α及CRP水平均显著降低,且观察组均显著低于对照组(P<0.05)。结论:参麦注射液与布地奈德联合治疗急性酒精中毒伴吸入性肺炎疗效可靠,能够有效缩短患者酒精中毒症状的恢复与消失时间,降低清醒后不良症状的发生率,并且能改善患者肝功能、减轻炎症反应,具有重要的临床价值。
Objective: To investigate the clinical efficacy of Shenmai injection combined with budesonide in the treatment of acute alcoholism and aspiration pneumonia. Methods: From June 2012 to June 2015, 112 patients with acute alcoholism and inhalation pneumonia admitted to our hospital were selected as the research objects. Random number method was used to divide them into observation group (57 cases) and control group 55 cases). The control group was treated with budesonide on the basis of the basic treatment. The observation group was treated with Shenmai injection on the basis of the control group. The symptom recovery time, the disappearance of symptoms and the adverse reactions after awake were collected and analyzed Condition, liver function index and serum inflammatory factor before and after treatment. Results: The awake time, the recovery time of blood pressure and the incidence of dizziness, headache and electrolyte disturbance in the observation group were significantly lower than those in the control group (P <0.05). After treatment, the aspartate aminotransferase (AST) Alanine aminotransferase (ALT), γ-glutamyl transferase (GGT) levels were significantly decreased, and the observation group were significantly lower than the control group (P <0.05); observed in patients with cough disappeared, asthma relief wheeze (P <0.05). After treatment, the levels of IL-6, TNF-α and CRP in the two groups were significantly decreased, and the observation group were significantly lower than the control group (P <0.05). Conclusion: Shenmai injection combined with budesonide in the treatment of acute alcoholism and aspiration pneumonia is reliable and can effectively shorten the recovery and disappearance time of symptoms of alcoholism, reduce the incidence of adverse symptoms after awake, and can improve the liver function , Reduce inflammation, has important clinical value.