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近年来注意到,高血脂病人用安定治疗失效的原因是由于安定药物动力学受影响。给9只兔,饲喂高胆固醇饲料7周导致高血脂,静脉注射安定0.5mg/kg,血样抽取到6小时;40例动脉血管硬化病例,其中半数血脂正常,半数高血脂,口服安定10mg,血样采取到36小时。应用电子捕获气相层析法测定安定血清浓度。从血药浓度数据,兔子按三隔室开放模型,病人按二隔室模型,用计算机计算血脂正常及高血脂兔与病人
In recent years, it has been noted that the reason for the failure of diazepam in hyperlipidemic patients is due to the effects of diazepam pharmacokinetics. Nine rabbits fed high cholesterol diet for 7 weeks resulted in hyperlipidemia. Intravenous injection of diazepam was 0.5 mg / kg and blood samples were taken for 6 hours. 40 cases of arteriosclerosis were observed, of which half of normal blood lipids and half of hyperlipidemia were orally administered 10 mg, Blood taken to 36 hours. Determination of stable serum concentration by electron capture gas chromatography. From the blood concentration data, rabbits according to the three-compartment open model, the patient according to two-compartment model, with the calculation of normal blood lipids and hyperlipidemic rabbits and patients